US2025145663A1 is a patent application reproduced in the source archive dental-enamel dossier under the title "Substrates comprising elastin-like polypeptides and calcium ions." It is the dossier's central patent document and shares its title and abstract with US2024301032A1 — Substrates Comprising Elastin-Like Polypeptides and Calcium Ions, indicating a common family.
Claimed subject matter
As quoted in the dossier, the disclosure is "directed towards polypeptide substrates and methods of synthesis thereof." Such substrates "can be embedded with calcium ions from a number of ionic sources." The calcium-embedded polypeptide substrates "can be used to grow a variety of crystal structures including flower-shaped, onion-shaped, and needle-like crystal structures," and the disclosure is "additionally directed towards methods of crystal growth from polypeptide substrates." The stated application scope is broad: "Compositions of the disclosure can be used in a wide variety of medical and other applications."
Scope caveat
The patent claims generic polypeptide-templated crystal growth across multiple morphologies and a wide range of applications. The associated paper (Abshar Hasan, Nature Communications 2025) reports enamel restoration specifically. The patent's breadth should not be read as evidence that enamel restoration was demonstrated, and the paper's specific result should not be read as validating the patent's general claims. See Patent as Evidence.
The dossier does not state the inventors, filing dates, or whether the "elastin-like polypeptides" of the title are the same elastin-like recombinamers described in the paper.
Related pages
- US2024301032A1 — Substrates Comprising Elastin-Like Polypeptides and Calcium Ions — companion application in the same family.
- Elastin-like Recombinamers (ELRs) — the material class named in the title.
Source notes & attribution
- https://rexresearch.com/ChenHasanToothRegeneration/ChenHasanToothRegrowth.html