US2018236130A1 — Amelogenin-Chitosan Hydrogel for Dentin Hypersensitivity

US2018236130A1 is a patent application reproduced in the source archive dental-enamel dossier under the title "Amelogenin-chitosan hydrogel for dentin hypersensitivity."

Claimed subject matter

As quoted in the dossier, the application claims "a method to regrow a protective layer over exposed/demineralized dentin that includes a step of identifying a subject having exposed/demineralized dentin." The demineralized dentin is contacted with "a remineralization composition that includes an amelogenin and derived peptides, a chitosan, water, and a sufficient amount of a pH adjusting component such that the composition has a pH greater than about 6.0," with the result that "dentinal tubules are occluded with apatite crystals and enamel is regrown on the dentinal tubules."

Material distinction

This is an amelogenin/chitosan carrier system with a specified pH condition (greater than about 6.0). It is a different material from the elastin-like recombinamer matrix of the Nature Communications paper and from the fluoro-calcium silicate system of CN109288685A — Amelogenin-Induced Fluoro-Calcium Silicate Biomimetic Mineralization. Claims should remain attached to this document. See Patent as Evidence.

Related pages

• CN109288685A — Amelogenin-Induced Fluoro-Calcium Silicate Biomimetic Mineralization — the other amelogenin-based patent in the dossier.
• Dental Enamel — the target tissue, including the hypersensitivity indication.